loading...| Preferred Name | infantile hypertrophic pyloric stenosis | |
| Synonyms |
congenital or infantile stricture of pylorus infantile pyloric stenosis congenital hypertrophic pyloric stenosis congenital constriction of the pylorus hypertrophic pyloric stenosis infantile hypertrophic pyloric stenosis pyloric stenosis, infantile infantile constriction of the pylorus congenital stricture of the pylorus congenital Hypertrophy of the pylorus infantile stricture of the pylorus infantile Hypertrophy of the pylorus congenital pyloric stenosis IHPS |
|
| Definitions |
This condition is caused by diffuse hypertrophy and hyperplasia of the smooth muscle of the antrum of the stomach and pylorus. It usually occurs in infants aged 2-8 weeks. The pyloric muscle hypertrophy results in narrowing of the pyloric canal, which can then become easily obstructed. Genetic studies have identified susceptibility loci for infantile hypertrophic pyloric stenosis (IHPS) and molecular studies have concluded that smooth muscle cells are not properly innervated in this condition. An abnormality characterized by thickening of the muscle in the wall of the pylorus. It results in the narrowing of the pyloric channel. The overlying mucosa may appear hypertrophic as well. Clinical signs and symptoms appear early in life and include projectile vomiting and dehydration. |
|
| ID |
http://www.ebi.ac.uk/efo/EFO_0004707 |
|
| database_cross_reference |
NCIT:C98952 ICD10CM:Q40.0 MONDO:0001560 MESH:D046248 SCTID:48644003 DOID:12638 ICD9:750.5 |
|
| definition |
This condition is caused by diffuse hypertrophy and hyperplasia of the smooth muscle of the antrum of the stomach and pylorus. It usually occurs in infants aged 2-8 weeks. The pyloric muscle hypertrophy results in narrowing of the pyloric canal, which can then become easily obstructed. Genetic studies have identified susceptibility loci for infantile hypertrophic pyloric stenosis (IHPS) and molecular studies have concluded that smooth muscle cells are not properly innervated in this condition. An abnormality characterized by thickening of the muscle in the wall of the pylorus. It results in the narrowing of the pyloric channel. The overlying mucosa may appear hypertrophic as well. Clinical signs and symptoms appear early in life and include projectile vomiting and dehydration. |
|
| definition_citation |
Panteli C; New insights into the pathogenesis of infantile pyloric stenosis. Pediatr Surg Int. 2009 Dec;25(12):1043-52. Epub 2009 Sep 16. [abstract] |
|
| gwas_trait |
true |
|
| has_exact_synonym |
congenital or infantile stricture of pylorus infantile pyloric stenosis congenital hypertrophic pyloric stenosis congenital constriction of the pylorus hypertrophic pyloric stenosis infantile hypertrophic pyloric stenosis pyloric stenosis, infantile infantile constriction of the pylorus congenital stricture of the pylorus congenital Hypertrophy of the pylorus infantile stricture of the pylorus infantile Hypertrophy of the pylorus congenital pyloric stenosis IHPS |
|
| id |
EFO:0004707 |
|
| in_subset | ||
| label |
infantile hypertrophic pyloric stenosis |
|
| notation |
EFO:0004707 |
|
| preferred label |
infantile hypertrophic pyloric stenosis |
|
| prefLabel |
infantile hypertrophic pyloric stenosis |
|
| skos_exactMatch |
http://identifiers.org/mesh/D046248 http://purl.obolibrary.org/obo/NCIT_C98952 http://purl.obolibrary.org/obo/DOID_12638 http://purl.obolibrary.org/obo/EFO_0004707 |
|
| term editor |
Helen Parkinson |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://www.ebi.ac.uk/efo/EFO_0004707 | EFO | SAME_URI | |
| http://www.ebi.ac.uk/efo/EFO_0004707 | EFO | SAME_URI | |
| http://www.ebi.ac.uk/efo/EFO_0004707 | EFO | LOOM | |
| http://www.ebi.ac.uk/efo/EFO_0004707 | EFO | LOOM | |
| http://purl.jp/bio/4/id/200906094743561180 | IOBC | LOOM |