loading...| Preferred Name | glioblastoma multiforme | |
| Synonyms |
grade IV adult astrocytic tumor grade IV adult astrocytic tumour giant cell glioblastoma (histologic variant) gliosarcoma (histologic variant) glioblastoma grade IV astrocytic neoplasm glioblastoma multiforme (disease) grade IV astrocytic tumour WHO grade IV glioma GBM (glioblastoma) grade IV astrocytic tumor grade IV astrocytoma glioblastoma (disease) spongioblastoma multiforme glioblastoma multiforme primary glioblastoma multiforme GBM |
|
| Definitions |
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) |
|
| ID |
http://www.ebi.ac.uk/efo/EFO_0000519 |
|
| closeMatch |
http://identifiers.org/snomedct/63634009 http://linkedlifedata.com/resource/umls/id/C1514422 http://purl.obolibrary.org/obo/NCIT_C39750 http://identifiers.org/snomedct/269506004 |
|
| database_cross_reference |
ONCOTREE:GB GARD:0002491 UMLS:CN227279 MedDRA:10018337 MedDRA:10018336 MESH:D005909 ICDO:9440/3 MONDO:0018177 SCTID:393563007 MEDGEN:42228 UMLS:C1621958 ONCOTREE:GBM UMLS:C0017636 NANDO:2200087 ICD10:C71.9 Orphanet:360 DOID:3068 GARD:2491 HP:0012174 HP:0100843 NCIT:C3058 NORD:1187 |
|
| definition |
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) |
|
| exactMatch |
http://identifiers.org/meddra/10018337 http://linkedlifedata.com/resource/umls/id/C0017636 http://identifiers.org/meddra/10018336 http://identifiers.org/snomedct/393563007 http://identifiers.org/mesh/D005909 http://purl.obolibrary.org/obo/DOID_3068 http://linkedlifedata.com/resource/umls/id/C1621958 |
|
| gwas_trait |
true |
|
| has_exact_synonym |
glioblastoma grade IV astrocytic neoplasm grade IV adult astrocytic tumor glioblastoma multiforme (disease) grade IV astrocytic tumour WHO grade IV glioma GBM (glioblastoma) grade IV astrocytic tumor grade IV astrocytoma glioblastoma (disease) spongioblastoma multiforme glioblastoma multiforme primary glioblastoma multiforme GBM |
|
| has_narrow_synonym |
grade IV adult astrocytic tumor grade IV adult astrocytic tumour |
|
| has_related_synonym |
giant cell glioblastoma (histologic variant) gliosarcoma (histologic variant) |
|
| IAO_0000233 | ||
| IAO_0000589 |
glioblastoma (disease) |
|
| id |
EFO:0000519 |
|
| in_subset |
http://purl.obolibrary.org/obo/mondo/mondo-base#rare http://purl.obolibrary.org/obo/mondo#ordo_disease http://purl.obolibrary.org/obo/mondo/mondo-base#otar http://purl.obolibrary.org/obo/mondo/mondo-base#gard_rare http://purl.obolibrary.org/obo/mondo/mondo-base#orphanet_rare http://purl.obolibrary.org/obo/mondo/mondo-base#nord_rare http://purl.obolibrary.org/obo/mondo/mondo-base#ordo_disorder |
|
| label |
glioblastoma multiforme |
|
| notation |
EFO:0000519 |
|
| preferred label |
glioblastoma multiforme |
|
| prefLabel |
glioblastoma multiforme |
|
| skos_closeMatch | ||
| skos_exactMatch |
http://linkedlifedata.com/resource/umls/id/C0017636 http://purl.obolibrary.org/obo/Orphanet_360 http://purl.obolibrary.org/obo/EFO_0000519 http://identifiers.org/snomedct/393563007 http://identifiers.org/mesh/D005909 http://purl.obolibrary.org/obo/DOID_3068 |
|
| subClassOf |