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Cell Culture Ontology
Last uploaded:
July 23, 2014
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| Id | http://purl.obolibrary.org/obo/HP_0001397
http://purl.obolibrary.org/obo/HP_0001397
|
|---|---|
| Preferred Name | Hepatic steatosis |
| Definitions |
Steatosis is a term used to denote lipid accumulation within hepatocytes.
Although steatosis is the hallmark of the fatty liver disease, it is not a specific feature because it can be seen as part of other disease processes, such as drug injury, Wilson disease, or hepatitis C virus infection (especially genotype-3). Involvement of less than 5% of the hepatocytes by steatosis is considered clinically insignificant and within reference range. Based on the morphologic appearance and the size of the lipid droplets within the cytoplasm of the hepatocytes, steatosis is characterized as macrovesicular or microvesicular. Macrovesicular steatosis is characterized by large lipid droplets occupying the cytoplasm, displacing the nucleus to the periphery (large droplet macrovesicular steatosis) or multiple small lipid droplets of variable size occupying the cytoplasm with the nucleus maintaining its central location (small droplet macrovesicular steatosis). Microvesicular steatosis is characterized by innumerable tiny, relatively uniform lipid vacuoles that result in a bubbly appearance of the hepatocytes.
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| Synonyms |
Fatty liver
Liver steatosis
Fatty infiltration of liver
Steatosis
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Steatosis is a term used to denote lipid accumulation within hepatocytes. |
|---|---|
| preferred label |
Hepatic steatosis
|
| label |
Hepatic steatosis
|
| comment |
Although steatosis is the hallmark of the fatty liver disease, it is not a specific feature because it can be seen as part of other disease processes, such as drug injury, Wilson disease, or hepatitis C virus infection (especially genotype-3). Involvement of less than 5% of the hepatocytes by steatosis is considered clinically insignificant and within reference range. Based on the morphologic appearance and the size of the lipid droplets within the cytoplasm of the hepatocytes, steatosis is characterized as macrovesicular or microvesicular. Macrovesicular steatosis is characterized by large lipid droplets occupying the cytoplasm, displacing the nucleus to the periphery (large droplet macrovesicular steatosis) or multiple small lipid droplets of variable size occupying the cytoplasm with the nucleus maintaining its central location (small droplet macrovesicular steatosis). Microvesicular steatosis is characterized by innumerable tiny, relatively uniform lipid vacuoles that result in a bubbly appearance of the hepatocytes.
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| prefLabel |
Hepatic steatosis
|
| database_cross_reference |
SNOMEDCT_US:442191002
SNOMEDCT_US:197321007
SNOMEDCT:197321007
UMLS:C2711227
OMIM:228100
SNOMEDCT:442191002
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|
| notation |
HP:0001397
|
| id |
HP:0001397
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| gwas_trait |
true
|
| subClassOf | |
| has_alternative_id |
HP:0002252
HP:0200121
|
| type | |
| has_exact_synonym |
Fatty liver
Liver steatosis
Fatty infiltration of liver
Steatosis
|
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