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Cell Culture Ontology
Preferred Name | pro-B cell | |
Synonyms |
pre-B cell (Philadelphia nomenclature) pre-pro B cell progenitor B-cell pro-B-lymphocyte progenitor B cell progenitor B lymphocyte pro-B lymphocyte progenitor B-lymphocyte pro-B-cell |
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Definitions |
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. |
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ID |
http://purl.obolibrary.org/obo/CL_0000826 |
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comment |
Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
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database_cross_reference |
ZFA:0009349 BTO:0003104
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definition |
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.
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has_broad_synonym |
pre-pro B cell
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has_exact_synonym |
progenitor B-cell pro-B-lymphocyte progenitor B cell progenitor B lymphocyte pro-B lymphocyte progenitor B-lymphocyte pro-B-cell
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has_related_synonym |
pre-B cell (Philadelphia nomenclature)
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in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
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label |
pro-B cell
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preferred label |
pro-B cell
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prefixIRI |
CL:0000826
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prefLabel |
pro-B cell
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RO_0002175 | ||
subClassOf |
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