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Brain Region & Cell Type terminology
Last uploaded:
November 3, 2014
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| Id | http://www.semanticweb.org/ontologies/2009/9/Ontology1255357986125.owl#Perivascular_cell
http://www.semanticweb.org/ontologies/2009/9/Ontology1255357986125.owl#Perivascular_cell
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| Preferred Name | Perivascular cell |
| Type | http://www.w3.org/2002/07/owl#Class |
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Perivascular cell
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Perivascular cell
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Unlike the other types of microglia mentioned above, "perivascular" microglia refers to the location of the cell rather than its form/function. Perivascular microglia are mainly found encased within the walls of the basal lamina. They perform normal microglial functions, but unlike normal microglia they are replaced by bone marrow derived precursor cells on a regular basis and express MHC class II antigens regardless of the outside environment. Perivascular microglia also react strongly to macrophage differentiation antigens.[3] These microglia have been shown to be essential to repair of vascular walls, as shown by Ritter's experiments and observations on ischemic retinopathy. Perivascular microglia promote endothelial cell proliferation allowing new vessels to be formed and damaged vessels to be repaired. During repair and development, myeloid recruitment and differentiation into microglial cells is highly accelerated to accomplish these tasks.
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Ontology1255357986125:Perivascular_cell
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