Biological Pathway Taxonomy

Last uploaded: March 30, 2022
Id urn:agi-pathway:uuid-4638c0f8-cdd8-46fb-86d0-cda70bb65ed7
urn:agi-pathway:uuid-4638c0f8-cdd8-46fb-86d0-cda70bb65ed7
Preferred Name

Male Sex Determination

Synonyms
PathwayType: signaling
Organ_System: reproductive system
Organ: testis
Source: Biological Process
Description: Pathway is built manually using published studies.
NodeType: Pathway
Notes: Headnote: Embryos are gonadally identical, regardless of genetic sex, until a certain point in development when the testis-determining factor causes male sex organs to develop.The first known step of sexual differentiation of a normal XY fetus is the development of testes. The early stages of testicular formation in the second month of gestation requires the action of several genes, of which one of the earliest and most important is SRY, the sex-determining region of the Y chromosome. Signaling description: When complexed with the SF1 (NR5A1) protein, SRY acts as a transcription factor that can upregulate other transcription factors, most importantly SOX9, which then activates and forms a feedforward loop with FGF9. Sertoli cell proliferation and differentiation is mainly activated by FGF9. SOX9 expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a testis. The now induced Leydig cells of the testis then start secreting testosterone while the Sertoli cells produce anti-Müllerian hormone (AMH) to inhibit the creation of a female reproductive system.Besides NR5A1, other transcription factors such as SP1, WT1, GATA4, FOG2 (ZFPM2), SIX1/4 control expression of SRY. DAX1 (NR0B1) is an antagonist of male development. There is evidence from work on suppression of male development that DAX1 can interfere with function of NR5A1, and in turn transcription of SRY by recruiting corepressors.Gonadal target genes of SOX9 include AMH, FGF9, desert hedgehog (DHH), prostaglandin D synthase (PTGDS), and VANIN1 (VNN1).Prostaglandin D2 (PGD2) is necessary and sufficient to recruit cells that do not express SRY to express SOX9 and differentiate into Sertoli cells. Outcome effects: During testis differentiation, SRY, SOX9 and FGF9 act to downregulate the ovarian pathway by suppressing RSPO1 and WNT4, which promote the development of the gonad as an ovary. Highlighted proteins: Key players of male sex determination are highlighted in red. Key players of female sex determination (repressed) are highlighted in blue.
Pathway_Author: S. Sozin www.researchgate.net/profile/Sergey-Sozin
Link: https://mammal-profservices.pathwaystudio.com/app/sd?urn=urn:agi-pathway:uuid-4638c0f8-cdd8-46fb-86d0-cda70bb65ed7
Type http://www.w3.org/2002/07/owl#Class
Delete Subject Author Type Created
No notes to display
  • Problem retrieving properties:

Notes

Filter:
Add NCBO Web Widgets to your site for BPT
Widget type Widget demonstration
Jump To

Type a class name from BPT and jump to it in BioPortal

Get code
Form Autocomplete

Fill your form fields with classes from BPT

Get code
Example 1 (start typing the class name to get its full URI)

Example 2 (get the ID for a class)

Example 3 (get the preferred name for a class)
Visualization

Display a visualization for a given class in BPT

Get code
Tree Widget

Display a class tree with a search field for BPT

Get code