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Biological Pathway Taxonomy
Last uploaded:
March 30, 2022
Acronym | BPT |
Visibility | Public |
Description | Biological Pathway Taxonomy (BPT) - hierarchical taxonomy of cellular and molecular mechanisms, metabolic reactions, and diseases that can be shown as signaling pathways. BPT was created manually based on the Elsevier Pathway Collection available for public usage. There are 3 types of entities in BPT – pathway, group, and folder of pathways and groups. Group is the list of genes and proteins associated with biological function and diseases. Pathway is an interactive model of molecular interactions in human and mammalian cells described in the literature. Each model was reconstructed based on facts published in peer-reviewed journals, with manually quality control. BPT pathway entity includes several properties such as link to the model in Pathway Studio software which allows reading supported sentences from published articles and additional information about members. A list of members for each model can be provided by request. Property “network” describes maps without logical causal relationships between members to distinguish them from actual models of molecular mechanisms (“signaling”). The index folder contains all pathways and groups sorted alphabetically. |
Status | Alpha |
Format | OBO |
Contact | Anastasia Nesterova, nesterova.anastasia@gmail.com |
Categories | Biological Process, Cell, Health, Immunology, Protein, Subcellular |
Version | Released | Uploaded | Downloads |
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synonymes2022 (Parsed, Indexed, Metrics, Annotator, Error Diff) | 03/29/2022 | 03/30/2022 | OBO | CSV | RDF/XML |
2022 (Archived) | 03/29/2022 | 03/29/2022 | OBO |
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Id | urn:agi-pathway:uuid-4638c0f8-cdd8-46fb-86d0-cda70bb65ed7
urn:agi-pathway:uuid-4638c0f8-cdd8-46fb-86d0-cda70bb65ed7
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Preferred Name | Male Sex Determination |
Synonyms |
PathwayType: signaling
Organ_System: reproductive system
Organ: testis
Source: Biological Process
Description: Pathway is built manually using published studies.
NodeType: Pathway
Notes: Headnote: Embryos are gonadally identical, regardless of genetic sex, until a certain point in development when the testis-determining factor causes male sex organs to develop.The first known step of sexual differentiation of a normal XY fetus is the development of testes. The early stages of testicular formation in the second month of gestation requires the action of several genes, of which one of the earliest and most important is SRY, the sex-determining region of the Y chromosome. Signaling description: When complexed with the SF1 (NR5A1) protein, SRY acts as a transcription factor that can upregulate other transcription factors, most importantly SOX9, which then activates and forms a feedforward loop with FGF9. Sertoli cell proliferation and differentiation is mainly activated by FGF9. SOX9 expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a testis. The now induced Leydig cells of the testis then start secreting testosterone while the Sertoli cells produce anti-Müllerian hormone (AMH) to inhibit the creation of a female reproductive system.Besides NR5A1, other transcription factors such as SP1, WT1, GATA4, FOG2 (ZFPM2), SIX1/4 control expression of SRY. DAX1 (NR0B1) is an antagonist of male development. There is evidence from work on suppression of male development that DAX1 can interfere with function of NR5A1, and in turn transcription of SRY by recruiting corepressors.Gonadal target genes of SOX9 include AMH, FGF9, desert hedgehog (DHH), prostaglandin D synthase (PTGDS), and VANIN1 (VNN1).Prostaglandin D2 (PGD2) is necessary and sufficient to recruit cells that do not express SRY to express SOX9 and differentiate into Sertoli cells. Outcome effects: During testis differentiation, SRY, SOX9 and FGF9 act to downregulate the ovarian pathway by suppressing RSPO1 and WNT4, which promote the development of the gonad as an ovary. Highlighted proteins: Key players of male sex determination are highlighted in red. Key players of female sex determination (repressed) are highlighted in blue.
Pathway_Author: S. Sozin www.researchgate.net/profile/Sergey-Sozin
Link: https://mammal-profservices.pathwaystudio.com/app/sd?urn=urn:agi-pathway:uuid-4638c0f8-cdd8-46fb-86d0-cda70bb65ed7
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
label | Male Sex Determination
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prefLabel | Male Sex Determination
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database_cross_reference |
PS:PathwayType
PS:Description
PS:Pathway_Author
PS:Link
PS:Organ_System
PS:NodeType
PS:Notes
PS:Organ
PS:Source
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notation | uuid-4638c0f8-cdd8-46fb-86d0-cda70bb65ed7
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id | urn:agi-pathway:uuid-4638c0f8-cdd8-46fb-86d0-cda70bb65ed7
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subClassOf |
urn:agi-folder:m
urn:agi-folder:reproductive_biology
urn:agi-folder:reproductive_system
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type | |
has_exact_synonym | PathwayType: signaling
Organ_System: reproductive system
Organ: testis
Source: Biological Process
Description: Pathway is built manually using published studies.
NodeType: Pathway
Notes: Headnote: Embryos are gonadally identical, regardless of genetic sex, until a certain point in development when the testis-determining factor causes male sex organs to develop.The first known step of sexual differentiation of a normal XY fetus is the development of testes. The early stages of testicular formation in the second month of gestation requires the action of several genes, of which one of the earliest and most important is SRY, the sex-determining region of the Y chromosome. Signaling description: When complexed with the SF1 (NR5A1) protein, SRY acts as a transcription factor that can upregulate other transcription factors, most importantly SOX9, which then activates and forms a feedforward loop with FGF9. Sertoli cell proliferation and differentiation is mainly activated by FGF9. SOX9 expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a testis. The now induced Leydig cells of the testis then start secreting testosterone while the Sertoli cells produce anti-Müllerian hormone (AMH) to inhibit the creation of a female reproductive system.Besides NR5A1, other transcription factors such as SP1, WT1, GATA4, FOG2 (ZFPM2), SIX1/4 control expression of SRY. DAX1 (NR0B1) is an antagonist of male development. There is evidence from work on suppression of male development that DAX1 can interfere with function of NR5A1, and in turn transcription of SRY by recruiting corepressors.Gonadal target genes of SOX9 include AMH, FGF9, desert hedgehog (DHH), prostaglandin D synthase (PTGDS), and VANIN1 (VNN1).Prostaglandin D2 (PGD2) is necessary and sufficient to recruit cells that do not express SRY to express SOX9 and differentiate into Sertoli cells. Outcome effects: During testis differentiation, SRY, SOX9 and FGF9 act to downregulate the ovarian pathway by suppressing RSPO1 and WNT4, which promote the development of the gonad as an ovary. Highlighted proteins: Key players of male sex determination are highlighted in red. Key players of female sex determination (repressed) are highlighted in blue.
Pathway_Author: S. Sozin www.researchgate.net/profile/Sergey-Sozin
Link: https://mammal-profservices.pathwaystudio.com/app/sd?urn=urn:agi-pathway:uuid-4638c0f8-cdd8-46fb-86d0-cda70bb65ed7
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treeView |
urn:agi-folder:m
urn:agi-folder:reproductive_biology
urn:agi-folder:reproductive_system
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