BioModels Ontology

Last uploaded: April 3, 2012
Preferred Name

cisapride

Definitions

The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.

ID

http://purl.obolibrary.org/obo/CHEBI_3720

alternative term

cis-4-amino-5-chloro-N-(1-(3-(p-fluorophenoxy)propyl)-3-methoxy-4-piperidyl)-o-anisamide

cisapridum

(+-)-cisapride

cisapride

cis-4-amino-5-chloro-N-{1-[3-(p-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl}-o-anisamide

cisaprida

4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide

InChIKey=DCSUBABJRXZOMT-IRLDBZIGSA-N

4-amino-5-chloro-N-{cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide

4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide

CO[C@H]1CN(CCCOc2ccc(F)cc2)CC[C@H]1NC(=O)c1cc(Cl)c(N)cc1OC

Cisapride

cis-4-amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl}-2-methoxybenzamide

InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)/t20-,22+/m1/s1

definition

The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.

has role

http://purl.obolibrary.org/obo/CHEBI_35941

http://purl.obolibrary.org/obo/CHEBI_55324

http://purl.obolibrary.org/obo/CHEBI_49201

label

cisapride

prefixIRI

CHEBI:3720

prefLabel

cisapride

subClassOf

http://purl.obolibrary.org/obo/CHEBI_26151

http://purl.obolibrary.org/obo/CHEBI_22702

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http://www.drugbank.ca/drugs/DB00604 FTC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU012783 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.621.135 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D020117 MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041689 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0072916 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/4001-0030 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.100.050.500.700 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14735 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148339 NDFRT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1210 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1210 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1210 NCIT LOOM
http://purl.bioontology.org/ontology/LNC/LP21146-3 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_3720 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3720 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3720 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3720 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3720 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3720 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3720 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3720 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3720 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3720 DRON SAME_URI
http://purl.bioontology.org/ontology/SNMI/C-84990 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.127.085.135 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907038303793124 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/A03FA02 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.100.200.374 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/dhj.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D020117 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.127.020.937.700 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4020825 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/35255 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Cisapride GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.127.250.374 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.277.135 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.100.100.135 RH-MESH LOOM
http://purl.jp/bio/4/id/200906001025099160 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387164008 SNOMEDCT LOOM