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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C999
http://purl.obolibrary.org/obo/NCIT_C999
|
|---|---|
| Preferred Name | Amonafide Dihydrochloride |
| Definitions |
The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis. |
|---|---|
| label | Amonafide Dihydrochloride
|
| prefLabel | Amonafide Dihydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| Legacy Concept Name | Amonafide
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| in_subset | |
| Preferred_Name | Amonafide Dihydrochloride
|
| Chemical_Formula | C16H17N3O2.2ClH
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| PDQ_Open_Trial_Search_ID | 40214
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| UMLS_CUI | C0051733
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| FDA_UNII_Code | 2UAV344O66
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| prefixIRI | NCIT:C999
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| NCI_Drug_Dictionary_ID | 40214
|
| Contributing_Source | FDA
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| subClassOf | |
| code | C999
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.
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| NSC Number | 308847
|
| PDQ_Closed_Trial_Search_ID | 40214
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 150091-68-2
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| Delete | Subject | Author | Type | Created |
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