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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C99640
http://purl.obolibrary.org/obo/NCIT_C99640
|
|---|---|
| Preferred Name | Landogrozumab |
| Definitions |
A monoclonal antibody against myostatin (MSTN) with potential anti-cachexia activity. Upon administration, landogrozumab binds to and neutralizes the MSTN protein, thereby blocking the MSTN signalling pathway. This may help decrease muscle protein breakdown and muscle weakness and may attenuate cancer cachexia. MSTN, a member of the transforming growth factor-beta (TGF-beta) superfamily, is a negative regulator of muscle growth and development.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A monoclonal antibody against myostatin (MSTN) with potential anti-cachexia activity. Upon administration, landogrozumab binds to and neutralizes the MSTN protein, thereby blocking the MSTN signalling pathway. This may help decrease muscle protein breakdown and muscle weakness and may attenuate cancer cachexia. MSTN, a member of the transforming growth factor-beta (TGF-beta) superfamily, is a negative regulator of muscle growth and development. |
|---|---|
| prefLabel | Landogrozumab
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| label | Landogrozumab
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| PDQ_Closed_Trial_Search_ID | 722359
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| code | C99640
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| Has_Target | |
| prefixIRI | NCIT:C99640
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| in_subset |
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| Display_Name | Landogrozumab
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| Preferred_Name | Landogrozumab
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| FDA_UNII_Code | B1792M902R
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
Anti-myostatin Monoclonal Antibody LY2495655
Landogrozumab
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| CAS_Registry | 1391726-30-9
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| NCI_Drug_Dictionary_ID | 722359
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 722359
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C3274844
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| Delete | Subject | Author | Type | Created |
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| No notes to display |