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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C99162
http://purl.obolibrary.org/obo/NCIT_C99162
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|---|---|
| Preferred Name | Monoclonal Antibody AbGn-7 |
| Definitions |
A chimeric monoclonal antibody against a Lewis-A-like glycotope (AbGn-7 antigen) with potential immunomodulating and antineoplastic activities. Monoclonal antibody AbGn-7 targets and binds to the carbohydrate AbGn-7 antigen on the cell surface of tumor cells and may induce complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC), thereby killing AbGn-7-epitope positive tumor cells. AbGn-7 antigen is expressed on a variety of tumor cell types, including human colorectal, pancreatic and gastric tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A chimeric monoclonal antibody against a Lewis-A-like glycotope (AbGn-7 antigen) with potential immunomodulating and antineoplastic activities. Monoclonal antibody AbGn-7 targets and binds to the carbohydrate AbGn-7 antigen on the cell surface of tumor cells and may induce complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC), thereby killing AbGn-7-epitope positive tumor cells. AbGn-7 antigen is expressed on a variety of tumor cell types, including human colorectal, pancreatic and gastric tumor cells. |
|---|---|
| prefLabel | Monoclonal Antibody AbGn-7
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| label | Monoclonal Antibody AbGn-7
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| NCI_META_CUI | CL433012
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| PDQ_Closed_Trial_Search_ID | 717457
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| code | C99162
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| prefixIRI | NCIT:C99162
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| in_subset |
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| Display_Name | Monoclonal Antibody AbGn-7
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| Preferred_Name | Monoclonal Antibody AbGn-7
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| Contributing_Source | CTRP
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| Maps_To | Monoclonal Antibody AbGn-7
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| NCI_Drug_Dictionary_ID | 717457
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 717457
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| Semantic_Type |
Pharmacologic Substance
Immunologic Factor
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