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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C99123
http://purl.obolibrary.org/obo/NCIT_C99123
|
|---|---|
| Preferred Name | Sirexatamab |
| Definitions |
A humanized monoclonal antibody directed against the WNT antagonist dickkopf homolog 1 (DKK1), with potential anti-osteolytic activity. Upon administration, sirexatamab binds to and inhibits DKK1, thereby restoring signaling through the WNT pathway, which may result in osteoblast differentiation and activation within the bone matrix and the reversal of tumor-induced osteolytic disease. DKK1, overexpressed by certain cancer cells, is an inhibitor of the WNT signaling pathway and prevents the mediated formation of bone.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized monoclonal antibody directed against the WNT antagonist dickkopf homolog 1 (DKK1), with potential anti-osteolytic activity. Upon administration, sirexatamab binds to and inhibits DKK1, thereby restoring signaling through the WNT pathway, which may result in osteoblast differentiation and activation within the bone matrix and the reversal of tumor-induced osteolytic disease. DKK1, overexpressed by certain cancer cells, is an inhibitor of the WNT signaling pathway and prevents the mediated formation of bone. |
|---|---|
| prefLabel | Sirexatamab
|
| label | Sirexatamab
|
| NCI_META_CUI | CL432944
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| PDQ_Closed_Trial_Search_ID | 715663
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| code | C99123
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| Has_Target | |
| prefixIRI | NCIT:C99123
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| in_subset |
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| Display_Name | Sirexatamab
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| Preferred_Name | Sirexatamab
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| FDA_UNII_Code | RM898LZ4SI
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
DKK1-Neutralizing Monoclonal Antibody DKN-01
Anti-DKK-1 Monoclonal Antibody LY2812176
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| CAS_Registry | 2414962-49-3
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| NCI_Drug_Dictionary_ID | 715663
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 715663
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| Delete | Subject | Author | Type | Created |
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| No notes to display |