Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C985
http://purl.obolibrary.org/obo/NCIT_C985
|
|---|---|
| Preferred Name | Acitretin |
| Definitions |
An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04) |
|---|---|
| prefLabel | Acitretin
|
| label | Acitretin
|
| CHEBI_ID | CHEBI:50173
|
| PDQ_Closed_Trial_Search_ID | 43244
|
| code | C985
|
| prefixIRI | NCIT:C985
|
| in_subset | |
| Preferred_Name | Acitretin
|
| FDA_UNII_Code | LCH760E9T7
|
| Contributing_Source | FDA
|
| Chemical_Formula | C21H26O3
|
| Maps_To | Acitretin
|
| CAS_Registry | 55079-83-9
|
| NCI_Drug_Dictionary_ID | 43244
|
| Legacy Concept Name | Acitretin
|
| type | |
| ALT_DEFINITION | A substance that is used in the prevention of cancer and in the treatment of psoriasis. It belongs to the family of drugs called retinoids.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43244
|
| Accepted_Therapeutic_Use_For | Psoriasis; cutaneous T-cell lymphoma
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0050559
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |