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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C98250
http://purl.obolibrary.org/obo/NCIT_C98250
|
|---|---|
| Preferred Name | Bardoxolone Methyl |
| Definitions |
The methyl ester form of bardoxolone, a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The methyl ester form of bardoxolone, a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression. |
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| prefLabel | Bardoxolone Methyl
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| label | Bardoxolone Methyl
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| code | C98250
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| Has_Target | |
| prefixIRI | NCIT:C98250
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| in_subset |
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| Display_Name | Bardoxolone Methyl
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| Preferred_Name | Bardoxolone Methyl
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| FDA_UNII_Code | CEG1Q6OGU1
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C32H43NO4
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| Maps_To | Bardoxolone Methyl
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| CAS_Registry | 218600-53-4
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| NSC Number | 713200
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1100924
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