Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Biguanide Antidiabetic Agent
Synonyms
Definitions

Any antidiabetic agent with the biguanide base structure or phenformin derivatives with antihyperglycemic activity. Biguanide antidiabetic agents activate AMP-activated protein kinase (AMPK) resulting in decreased glucose production in the liver, increased peripheral glucose uptake and improved utilization of glucose. Biguanide-based antidiabetic agents do not cause hypoglycemia. In addition, biguanide antidiabetics decrease absorption of glucose from the gastrointestinal tract.
ID

http://purl.obolibrary.org/obo/NCIT_C98234
code

C98234
Contributing_Source

GDC
definition

Any antidiabetic agent with the biguanide base structure or phenformin derivatives with antihyperglycemic activity. Biguanide antidiabetic agents activate AMP-activated protein kinase (AMPK) resulting in decreased glucose production in the liver, increased peripheral glucose uptake and improved utilization of glucose. Biguanide-based antidiabetic agents do not cause hypoglycemia. In addition, biguanide antidiabetics decrease absorption of glucose from the gastrointestinal tract.
in_subset

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C157711
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C99532
label

Biguanide Antidiabetic Agent
Maps_To

Biguanide
Preferred_Name

Biguanide Antidiabetic Agent
prefixIRI

NCIT:C98234
prefLabel

Biguanide Antidiabetic Agent
Semantic_Type

Pharmacologic Substance

Chemical Viewed Functionally
UMLS_CUI

C3273895
subClassOf

http://purl.obolibrary.org/obo/NCIT_C29711
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