Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C982
http://purl.obolibrary.org/obo/NCIT_C982
Preferred Name

Chloroquinoxaline Sulfonamide
Definitions
A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04)
prefLabel
Chloroquinoxaline Sulfonamide
label
Chloroquinoxaline Sulfonamide
PDQ_Closed_Trial_Search_ID
41055
code
C982
prefixIRI
NCIT:C982
in_subset
Preferred_Name
Chloroquinoxaline Sulfonamide
FDA_UNII_Code
O0408QB48D
Contributing_Source
FDA
Maps_To
Chloroquinoxaline Sulfonamide
CAS_Registry
97919-22-7
NSC Number
339004
NCI_Drug_Dictionary_ID
41055
Legacy Concept Name
Chloroquinoxaline_Sulfonamide
type
ALT_DEFINITION
A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
41055
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0049111
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