Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

SGLT2 Inhibitor
Synonyms
Definitions

Any inhibitor of the sodium-glucose co-transporter subtype 2 (SGLT2) with antihyperglycemic activity. By binding to and blocking SGLT2, these inhibitors suppress reabsorption of glucose in the proximal tubule within the kidneys and thereby enhancing urinary excretion of glucose. This eventually normalizes blood glucose levels. SGLT2, a transport system exclusively expressed in the proximal renal tubules, mediates about 90% of renal glucose reabsorption from tubular fluid.
ID

http://purl.obolibrary.org/obo/NCIT_C98083
code

C98083
Contributing_Source

CTRP
definition

Any inhibitor of the sodium-glucose co-transporter subtype 2 (SGLT2) with antihyperglycemic activity. By binding to and blocking SGLT2, these inhibitors suppress reabsorption of glucose in the proximal tubule within the kidneys and thereby enhancing urinary excretion of glucose. This eventually normalizes blood glucose levels. SGLT2, a transport system exclusively expressed in the proximal renal tubules, mediates about 90% of renal glucose reabsorption from tubular fluid.
Display_Name

SGLT2 Inhibitor
Has_Target

http://purl.obolibrary.org/obo/NCIT_C119006
in_subset

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978
label

SGLT2 Inhibitor
Preferred_Name

SGLT2 Inhibitor
prefixIRI

NCIT:C98083
prefLabel

SGLT2 Inhibitor
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C3273807
subClassOf

http://purl.obolibrary.org/obo/NCIT_C471

http://purl.obolibrary.org/obo/NCIT_C29711
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