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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C979
http://purl.obolibrary.org/obo/NCIT_C979
|
|---|---|
| Preferred Name | Lometrexol |
| Definitions |
A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. (NCI04) |
|---|---|
| prefLabel | Lometrexol
|
| label | Lometrexol
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| PDQ_Closed_Trial_Search_ID | 41670
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| code | C979
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| prefixIRI | NCIT:C979
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| in_subset | |
| Preferred_Name | Lometrexol
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| FDA_UNII_Code | 6P3AVY8A7Q
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| Contributing_Source | FDA
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| Chemical_Formula | C21H25N5O6
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| Maps_To | Lometrexol
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| CAS_Registry | 106400-81-1
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| NSC Number | 660025
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| NCI_Drug_Dictionary_ID | 41670
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| Legacy Concept Name | Lometrexol
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| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called antifolates.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41670
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0048852
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