Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C975 http://purl.obolibrary.org/obo/NCIT_C975
Preferred Name	Afimoxifene
Definitions	A tamoxifen metabolite with both estrogenic and anti-estrogenic effects. Afimoxifene has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells.
Type	http://www.w3.org/2002/07/owl#Class

definition	A tamoxifen metabolite with both estrogenic and anti-estrogenic effects. Afimoxifene has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells.
prefLabel	Afimoxifene
label	Afimoxifene
CHEBI_ID	CHEBI:44616
PDQ_Closed_Trial_Search_ID	371709
code	C975
Has_Target	http://purl.obolibrary.org/obo/NCIT_C38361
prefixIRI	NCIT:C975
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Display_Name	Afimoxifene
Preferred_Name	Afimoxifene
FDA_UNII_Code	17197F0KYM
Contributing_Source	CTRP FDA
Maps_To	Afimoxifene
CAS_Registry	68047-06-3 68392-35-8
NCI_Drug_Dictionary_ID	371709
Legacy Concept Name	_4-Hydroxy-Tamoxifen
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A form of the drug tamoxifen that is made by the body after taking tamoxifen. It can also be made in the laboratory, and may help decrease breast density. A topical form of 4-hydroxytamoxifen is being studied in breast cancer screening.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C1821
PDQ_Open_Trial_Search_ID	371709
Semantic_Type	Organic Chemical Pharmacologic Substance
UMLS_CUI	C2347999

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