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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Pegloticase | |
| Synonyms |
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| Definitions |
A recombinant modified mammalian urate oxidase (uricase) conjugated to monomethoxypolyethylene glycol (mPEG), that can be used to lower serum uric acid. Upon intravenous infusion, pegloticase catalyzes the oxidation of uric acid to allantoin, thereby lowering serum uric acid. Allantoin is an inert and water-soluble purine metabolite; it is readily eliminated, primarily by renal excretion. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C97466 |
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| CAS_Registry |
885051-90-1
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|
| code |
C97466
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
A recombinant modified mammalian urate oxidase (uricase) conjugated to monomethoxypolyethylene glycol (mPEG), that can be used to lower serum uric acid. Upon intravenous infusion, pegloticase catalyzes the oxidation of uric acid to allantoin, thereby lowering serum uric acid. Allantoin is an inert and water-soluble purine metabolite; it is readily eliminated, primarily by renal excretion.
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| Display_Name |
Pegloticase
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| FDA_UNII_Code |
R581OT55EA
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Pegloticase
|
|
| NCI_Drug_Dictionary_ID |
804942
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|
| Preferred_Name |
Pegloticase
|
|
| prefixIRI |
NCIT:C97466
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| prefLabel |
Pegloticase
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C2350656
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| subClassOf |
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