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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C971
http://purl.obolibrary.org/obo/NCIT_C971
|
|---|---|
| Preferred Name | 4'-Iodo-4'-Deoxydoxorubicin |
| Definitions |
An iodinated doxorubicin analogue with antiamyloid activity. 4'-Iodo-4'-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural amyloid fibrils including immunoglobulin light chains, amyloid A, transthyretin (methionine-30 variant), beta-protein (Alzheimer), and beta2-microglobulin. This agent may inhibit fibril growth, increasing the solubility of amyloid tissue deposits and facilitating their clearance. IDOX has also been shown to insulin amyloid fibrillogenesis in vitro.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An iodinated doxorubicin analogue with antiamyloid activity. 4'-Iodo-4'-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural amyloid fibrils including immunoglobulin light chains, amyloid A, transthyretin (methionine-30 variant), beta-protein (Alzheimer), and beta2-microglobulin. This agent may inhibit fibril growth, increasing the solubility of amyloid tissue deposits and facilitating their clearance. IDOX has also been shown to insulin amyloid fibrillogenesis in vitro. |
|---|---|
| prefLabel | 4'-Iodo-4'-Deoxydoxorubicin
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| label | 4'-Iodo-4'-Deoxydoxorubicin
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| CHEBI_ID | CHEBI:47897
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| PDQ_Closed_Trial_Search_ID | 41162
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| code | C971
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| prefixIRI | NCIT:C971
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| in_subset |
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| Display_Name | 4'-Iodo-4'-Deoxydoxorubicin
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| Preferred_Name | 4'-Iodo-4'-Deoxydoxorubicin
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| FDA_UNII_Code | 65JH75I9JX
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| Contributing_Source |
CTRP
FDA
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| Maps_To | 4'-Iodo-4'-Deoxydoxorubicin
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| CAS_Registry | 83997-75-5
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| NSC Number | 378901
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| NCI_Drug_Dictionary_ID | 41162
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| Legacy Concept Name | _4_Iodo-4_Deoxydoxorubicin
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| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer, and for primary systemic amyloidosis (a disease in which proteins are deposited in specific organs). It belongs to the family of drugs called anthracycline analogues.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41162
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0047758
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