Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C96748
http://purl.obolibrary.org/obo/NCIT_C96748
|
|---|---|
| Preferred Name | Eribulin |
| Definitions |
An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. |
|---|---|
| prefLabel | Eribulin
|
| label | Eribulin
|
| Has_Salt_Form | |
| CHEBI_ID | CHEBI:63587
|
| code | C96748
|
| Has_Target | |
| prefixIRI | NCIT:C96748
|
| in_subset | |
| Preferred_Name | Eribulin
|
| FDA_UNII_Code | LR24G6354G
|
| Contributing_Source | FDA
|
| Chemical_Formula | C40H59NO11
|
| Maps_To | Eribulin
|
| CAS_Registry | 253128-41-5
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Accepted_Therapeutic_Use_For | Breast Cancer
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C2350866
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |