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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C96744
http://purl.obolibrary.org/obo/NCIT_C96744
|
|---|---|
| Preferred Name | Anti-prolactin Receptor Antibody LFA102 |
| Definitions |
A neutralizing antibody against the prolactin receptor (PRLR) with potential antineoplastic activity. Upon administration, anti-prolactin receptor antibody LFA102 binds to PRLR and prevents the binding of the peptide hormone prolactin (PRL) to its receptor. This binding induces an antibody-dependent cellular cytotoxicity (ADCC) and may eventually prevent tumor cell proliferation in PRLR-positive cancer cells. PRLR/PRL signaling pathway is frequently overexpressed in breast and prostate cancer.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A neutralizing antibody against the prolactin receptor (PRLR) with potential antineoplastic activity. Upon administration, anti-prolactin receptor antibody LFA102 binds to PRLR and prevents the binding of the peptide hormone prolactin (PRL) to its receptor. This binding induces an antibody-dependent cellular cytotoxicity (ADCC) and may eventually prevent tumor cell proliferation in PRLR-positive cancer cells. PRLR/PRL signaling pathway is frequently overexpressed in breast and prostate cancer. |
|---|---|
| prefLabel | Anti-prolactin Receptor Antibody LFA102
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| label | Anti-prolactin Receptor Antibody LFA102
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| NCI_META_CUI | CL429368
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| PDQ_Closed_Trial_Search_ID | 699731
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| code | C96744
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| Has_Target | |
| prefixIRI | NCIT:C96744
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| in_subset | |
| Display_Name | Anti-prolactin Receptor Antibody LFA102
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| Preferred_Name | Anti-prolactin Receptor Antibody LFA102
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| Contributing_Source | CTRP
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| Maps_To | Anti-prolactin Receptor Antibody LFA102
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| NCI_Drug_Dictionary_ID | 699731
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 699731
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| Semantic_Type | Pharmacologic Substance
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