Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C965
http://purl.obolibrary.org/obo/NCIT_C965
Preferred Name

2-Methoxyestradiol
Definitions
An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. (NCI04)
prefLabel
2-Methoxyestradiol
label
2-Methoxyestradiol
CHEBI_ID
CHEBI:28955
PDQ_Closed_Trial_Search_ID
38472
code
C965
Has_Target
prefixIRI
NCIT:C965
in_subset
Display_Name
2-Methoxyestradiol
Preferred_Name
2-Methoxyestradiol
FDA_UNII_Code
6I2QW73SR5
Contributing_Source
CTRP
FDA
Chemical_Formula
C19H26O3
Maps_To
2-Methoxyestradiol
CAS_Registry
362-07-2
NSC Number
659853
NCI_Drug_Dictionary_ID
38472
Legacy Concept Name
_2-Methoxyestradiol
type
ALT_DEFINITION
2ME2. A drug derived from estrogen that belongs to the family of drugs called angiogenesis inhibitors. It prevents the formation of new blood vessels that tumors need in order to grow.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
38472
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0046319
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