Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C963 http://purl.obolibrary.org/obo/NCIT_C963
Preferred Name	SarCNU
Definitions	An alkylating chloroethylnitrosourea with antineoplastic activity. Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	An alkylating chloroethylnitrosourea with antineoplastic activity. Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)
prefLabel	SarCNU
label	SarCNU
PDQ_Closed_Trial_Search_ID	43325
code	C963
Has_Target	http://purl.obolibrary.org/obo/NCIT_C449
prefixIRI	NCIT:C963
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Display_Name	SarCNU
Preferred_Name	SarCNU
FDA_UNII_Code	BHB013S3MO
Contributing_Source	CTRP FDA
Maps_To	SarCNU
CAS_Registry	92891-93-5
NSC Number	364432
NCI_Drug_Dictionary_ID	43325
Legacy Concept Name	SarCNU
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A substance being studied in the treatment of cancer. It is a type of alkylating agent.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C699
PDQ_Open_Trial_Search_ID	43325
Semantic_Type	Organic Chemical Pharmacologic Substance
UMLS_CUI	C0045644

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