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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C96227
http://purl.obolibrary.org/obo/NCIT_C96227
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|---|---|
| Preferred Name | cFMS Tyrosine Kinase Inhibitor ARRY-382 |
| Definitions |
A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation. |
|---|---|
| prefLabel | cFMS Tyrosine Kinase Inhibitor ARRY-382
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| label | cFMS Tyrosine Kinase Inhibitor ARRY-382
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| NCI_META_CUI | CL429011
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| PDQ_Closed_Trial_Search_ID | 697525
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| code | C96227
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| Has_Target | |
| prefixIRI | NCIT:C96227
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| in_subset | |
| Display_Name | cFMS Tyrosine Kinase Inhibitor ARRY-382
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| Preferred_Name | cFMS Tyrosine Kinase Inhibitor ARRY-382
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| Contributing_Source | CTRP
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| Maps_To | cFMS Tyrosine Kinase Inhibitor ARRY-382
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| NCI_Drug_Dictionary_ID | 697525
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 697525
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| Semantic_Type | Pharmacologic Substance
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