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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C961
http://purl.obolibrary.org/obo/NCIT_C961
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|---|---|
| Preferred Name | Gemcitabine Hydrochloride |
| Definitions |
The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. |
|---|---|
| prefLabel | Gemcitabine Hydrochloride
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| label | Gemcitabine Hydrochloride
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| CHEBI_ID | CHEBI:31647
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| PDQ_Closed_Trial_Search_ID | 41213
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| code | C961
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| Has_Target | |
| prefixIRI | NCIT:C961
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| in_subset |
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| Display_Name | Gemcitabine Hydrochloride
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| Preferred_Name | Gemcitabine Hydrochloride
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| FDA_UNII_Code | U347PV74IL
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C9H11F2N3O4.HCl
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| Maps_To | Gemcitabine Hydrochloride
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| CAS_Registry | 122111-03-9
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| NSC Number | 613327
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| NCI_Drug_Dictionary_ID | 41213
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| Legacy Concept Name | Gemcitabine
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug used to treat pancreatic cancer that is advanced or has spread. It is also used with other drugs to treat breast cancer that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Gemcitabine hydrochloride blocks the cell from making DNA and may kill cancer cells.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41213
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| Accepted_Therapeutic_Use_For | Bladder cancer; Breast cancer; Carcinoma of unknown primary origin; Lung cancer; including non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Renal cell carcinoma
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0771488
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