Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C95772
http://purl.obolibrary.org/obo/NCIT_C95772
Preferred Name

siG12D LODER
Definitions
A proprietary, miniature biodegradable polymeric matrix containing small-interfering RNAs for the mutated KRAS oncogene, KRASG12D, (siG12D), with potential antitumor activity. Upon intratumoral injection, this siG12D is released locally, thereby preventing translation of KRAS proteins and potentially inhibiting growth of tumor cells overexpressing KRAS. KRAS, a member of the small GTPase superfamily, is mutated in over 90% of human pancreatic ductal adenocarcinomas (PDAC) and is associated with tumor cell proliferation and reduced survival.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A proprietary, miniature biodegradable polymeric matrix containing small-interfering RNAs for the mutated KRAS oncogene, KRASG12D, (siG12D), with potential antitumor activity. Upon intratumoral injection, this siG12D is released locally, thereby preventing translation of KRAS proteins and potentially inhibiting growth of tumor cells overexpressing KRAS. KRAS, a member of the small GTPase superfamily, is mutated in over 90% of human pancreatic ductal adenocarcinomas (PDAC) and is associated with tumor cell proliferation and reduced survival.
prefLabel
siG12D LODER
label
siG12D LODER
NCI_META_CUI
CL428214
PDQ_Closed_Trial_Search_ID
685237
code
C95772
Has_Target
prefixIRI
NCIT:C95772
in_subset
Display_Name
siG12D LODER
Preferred_Name
siG12D LODER
FDA_UNII_Code
NNQ0PKZ9EV
Contributing_Source
CTRP
FDA
Maps_To
siG12D LODER
NCI_Drug_Dictionary_ID
685237
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
685237
Semantic_Type
Pharmacologic Substance
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