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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C95755
http://purl.obolibrary.org/obo/NCIT_C95755
|
|---|---|
| Preferred Name | Ulocuplumab |
| Definitions |
An orally bioavailable monoclonal antibody against CXC Chemokine Receptor 4 (CXCR4) with potential antineoplastic activity. Ulocuplumab binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and subsequent receptor activation, which may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable monoclonal antibody against CXC Chemokine Receptor 4 (CXCR4) with potential antineoplastic activity. Ulocuplumab binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and subsequent receptor activation, which may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types. |
|---|---|
| prefLabel | Ulocuplumab
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| label | Ulocuplumab
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| PDQ_Closed_Trial_Search_ID | 673715
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| code | C95755
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| Has_Target | |
| prefixIRI | NCIT:C95755
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| in_subset |
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| Display_Name | Ulocuplumab
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| Preferred_Name | Ulocuplumab
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| FDA_UNII_Code | 7KNP87L4X4
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Ulocuplumab
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| CAS_Registry | 1375830-34-4
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| NCI_Drug_Dictionary_ID | 673715
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 673715
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3658941
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