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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C95726
http://purl.obolibrary.org/obo/NCIT_C95726
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|---|---|
| Preferred Name | Lucitanib |
| Definitions |
A novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. Lucitanib inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. Lucitanib inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types. |
|---|---|
| prefLabel | Lucitanib
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| label | Lucitanib
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| PDQ_Closed_Trial_Search_ID | 694590
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| code | C95726
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| prefixIRI | NCIT:C95726
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| in_subset | |
| Preferred_Name | Lucitanib
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| FDA_UNII_Code | PP449XA4BH
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| Contributing_Source | FDA
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| Maps_To | Lucitanib
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| CAS_Registry | 1058137-23-7
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| NCI_Drug_Dictionary_ID | 694590
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 694590
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3887575
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