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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C95724
http://purl.obolibrary.org/obo/NCIT_C95724
|
|---|---|
| Preferred Name | MTF-1 Inhibitor APTO-253 HCl |
| Definitions |
The hydrochloride salt of a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor APTO-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt of a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor APTO-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis. |
|---|---|
| prefLabel | MTF-1 Inhibitor APTO-253 HCl
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| label | MTF-1 Inhibitor APTO-253 HCl
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| NCI_META_CUI | CL428185
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| PDQ_Closed_Trial_Search_ID | 694483
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| code | C95724
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| prefixIRI | NCIT:C95724
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| in_subset |
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| Display_Name | MTF-1 Inhibitor APTO-253 HCl
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| Preferred_Name | MTF-1 Inhibitor APTO-253 HCl
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| FDA_UNII_Code | 266N56YWTZ
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| Contributing_Source |
CTRP
FDA
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| Maps_To | MTF-1 Inhibitor APTO-253 HCl
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| CAS_Registry | 1422731-37-0
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| NCI_Drug_Dictionary_ID | 694483
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 694483
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| Semantic_Type | Pharmacologic Substance
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