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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C95718
http://purl.obolibrary.org/obo/NCIT_C95718
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|---|---|
| Preferred Name | Liposomal c-raf Antisense Oligonucleotide |
| Definitions |
The liposomal formulation of a c-raf-1 antisense oligonucleotide, with potential antineoplastic activity. Liposomal c-raf antisense oligonucleotide targets the translation initiation site of human c-raf-1 mRNA, thereby blocking the expression and production of Raf-1 protein and thus inhibit tumor cell growth and development. Raf-1 plays a key role in the RAF/MEK/ERK signaling pathway, which regulates mammalian cell proliferation and growth. The liposomal formulation increases the solubility of the c-raf antisense oligonucleotide, thus improving its pharmacodynamic profile.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The liposomal formulation of a c-raf-1 antisense oligonucleotide, with potential antineoplastic activity. Liposomal c-raf antisense oligonucleotide targets the translation initiation site of human c-raf-1 mRNA, thereby blocking the expression and production of Raf-1 protein and thus inhibit tumor cell growth and development. Raf-1 plays a key role in the RAF/MEK/ERK signaling pathway, which regulates mammalian cell proliferation and growth. The liposomal formulation increases the solubility of the c-raf antisense oligonucleotide, thus improving its pharmacodynamic profile. |
|---|---|
| prefLabel | Liposomal c-raf Antisense Oligonucleotide
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| label | Liposomal c-raf Antisense Oligonucleotide
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| PDQ_Closed_Trial_Search_ID | 419645
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| code | C95718
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| prefixIRI | NCIT:C95718
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| in_subset | |
| Preferred_Name | Liposomal c-raf Antisense Oligonucleotide
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| Maps_To | Liposomal c-raf Antisense Oligonucleotide
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| NCI_Drug_Dictionary_ID | 419645
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 419645
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C1436330
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