Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C95319
http://purl.obolibrary.org/obo/NCIT_C95319
|
|---|---|
| Preferred Name | Pirarubicin Hydrochloride |
| Definitions |
The hydrochloride salt form of pirarubicin, an analogue of the anthracycline antineoplastic antibiotic doxorubicin with antineoplastic activity. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt form of pirarubicin, an analogue of the anthracycline antineoplastic antibiotic doxorubicin with antineoplastic activity. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. |
|---|---|
| prefLabel | Pirarubicin Hydrochloride
|
| label | Pirarubicin Hydrochloride
|
| code | C95319
|
| prefixIRI | NCIT:C95319
|
| in_subset | |
| Preferred_Name | Pirarubicin Hydrochloride
|
| FDA_UNII_Code | E7V83174BE
|
| Contributing_Source | FDA
|
| Chemical_Formula | C32H37NO12.ClH
|
| Maps_To | Pirarubicin Hydrochloride
|
| CAS_Registry | 72496-41-4
|
| NSC Number | 333054
|
| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
|
| UMLS_CUI | C0898957
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |