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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C95208
http://purl.obolibrary.org/obo/NCIT_C95208
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|---|---|
| Preferred Name | Triazene Derivative TriN2755 |
| Definitions |
A synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, TriN2755 is converted into highly reactive carbocations that can alkylate DNA and other macromolecules, thereby resulting in DNA cross links, inhibiting DNA replication and repair, and subsequently inducing apoptosis. This agent has high hydrophilicity and photostability and shows a favorable toxicity profile over the other triazenes.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, TriN2755 is converted into highly reactive carbocations that can alkylate DNA and other macromolecules, thereby resulting in DNA cross links, inhibiting DNA replication and repair, and subsequently inducing apoptosis. This agent has high hydrophilicity and photostability and shows a favorable toxicity profile over the other triazenes. |
|---|---|
| prefLabel | Triazene Derivative TriN2755
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| label | Triazene Derivative TriN2755
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| NCI_META_CUI | CL426697
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| PDQ_Closed_Trial_Search_ID | 691486
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| code | C95208
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| prefixIRI | NCIT:C95208
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| in_subset | |
| Preferred_Name | Triazene Derivative TriN2755
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| Maps_To | Triazene Derivative TriN2755
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| NCI_Drug_Dictionary_ID | 691486
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 691486
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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