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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C95025
http://purl.obolibrary.org/obo/NCIT_C95025
|
|---|---|
| Preferred Name | Iodine I 131 Monoclonal Antibody F16SIP |
| Definitions |
A fully human monoclonal antibody (MoAb) against human A1 domain of tenascin-C, in small immunoprotein (SIP) format conjugated with iodine 131 with potential antineoplastic activity. Iodine I 131 MoAb F16SIP binds to tenascin-C on the vascular tissues and delivers cytotoxic radiation to the tumors, thereby minimizing systemic radiotoxicity. Tenascin-C is a glycoprotein of the extracellular matrix, and the large isoform of this matrix protein is expressed and restricted around vascular structures in the tumor stroma of a variety of different tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A fully human monoclonal antibody (MoAb) against human A1 domain of tenascin-C, in small immunoprotein (SIP) format conjugated with iodine 131 with potential antineoplastic activity. Iodine I 131 MoAb F16SIP binds to tenascin-C on the vascular tissues and delivers cytotoxic radiation to the tumors, thereby minimizing systemic radiotoxicity. Tenascin-C is a glycoprotein of the extracellular matrix, and the large isoform of this matrix protein is expressed and restricted around vascular structures in the tumor stroma of a variety of different tumors. |
|---|---|
| prefLabel | Iodine I 131 Monoclonal Antibody F16SIP
|
| label | Iodine I 131 Monoclonal Antibody F16SIP
|
| PDQ_Closed_Trial_Search_ID | 689747
|
| code | C95025
|
| prefixIRI | NCIT:C95025
|
| in_subset | |
| Preferred_Name | Iodine I 131 Monoclonal Antibody F16SIP
|
| Maps_To | Iodine I 131 Monoclonal Antibody F16SIP
|
| NCI_Drug_Dictionary_ID | 689747
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 689747
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C2986856
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