Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C94723
http://purl.obolibrary.org/obo/NCIT_C94723
Preferred Name

Chlorotoxin
Definitions
A neurotoxin with potential anticancer property. Chlorotoxin (CTX) is a 36-amino acid peptide found in the venom of the deathstalker scorpion, and a chloride channel blocker. This toxin binds preferentially to glioma cells via the transmembrane endopeptidase matrix metalloproteinase-2 (MMP-2), and thereby prevents the spread of tumor cells. MMP-2 is specifically up-regulated in gliomas and related cancers, but is not normally expressed in brain.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A neurotoxin with potential anticancer property. Chlorotoxin (CTX) is a 36-amino acid peptide found in the venom of the deathstalker scorpion, and a chloride channel blocker. This toxin binds preferentially to glioma cells via the transmembrane endopeptidase matrix metalloproteinase-2 (MMP-2), and thereby prevents the spread of tumor cells. MMP-2 is specifically up-regulated in gliomas and related cancers, but is not normally expressed in brain.
prefLabel
Chlorotoxin
label
Chlorotoxin
code
C94723
prefixIRI
NCIT:C94723
in_subset
Preferred_Name
Chlorotoxin
FDA_UNII_Code
06UV5RFW57
Contributing_Source
FDA
Maps_To
Chlorotoxin
CAS_Registry
163515-35-3
type
ALT_DEFINITION
A substance being studied in the diagnosis and treatment of glioma (a type of brain cancer) and other types of cancer. It binds to cancer cells in the brain and peripheral nervous system and may keep them from spreading. Chlorotoxin comes from the venom of a type of scorpion. A form of chlorotoxin made in the laboratory is called TM-601. Chlorotoxin is a type of neurotoxin.
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
Biologically Active Substance
UMLS_CUI
C0293227
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