loading...| Preferred Name |
Pentosan Polysulfate Sodium |
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| Synonyms |
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|
| Definitions |
The sodium salt of a semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties. In addition, pentosan polysulfate may block endothelial P-selectin and increase microvascular blood flow in sickle cell disease. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C946 |
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| CAS_Registry |
140207-93-8 |
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| Chemical_Formula |
(C5H6Na2O10S2)n |
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| code |
C946 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The sodium salt of a semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties. In addition, pentosan polysulfate may block endothelial P-selectin and increase microvascular blood flow in sickle cell disease. |
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| Display_Name |
Pentosan Polysulfate Sodium |
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| FDA_UNII_Code |
914032762Y |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Pentosan Polysulfate Sodium |
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| Legacy Concept Name |
Pentosan_Polysulfate_Sodium |
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| NCI_Drug_Dictionary_ID |
40350 |
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| PDQ_Closed_Trial_Search_ID |
40350 |
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| PDQ_Open_Trial_Search_ID |
40350 |
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| Preferred_Name |
Pentosan Polysulfate Sodium |
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| prefixIRI |
NCIT:C946 |
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| prefLabel |
Pentosan Polysulfate Sodium |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0524684 |
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| subClassOf |