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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C945
http://purl.obolibrary.org/obo/NCIT_C945
|
|---|---|
| Preferred Name | Warfarin |
| Definitions |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. |
|---|---|
| prefLabel | Warfarin
|
| label | Warfarin
|
| Has_Salt_Form | |
| CHEBI_ID | CHEBI:10033
|
| PDQ_Closed_Trial_Search_ID | 39740
|
| code | C945
|
| prefixIRI | NCIT:C945
|
| in_subset | |
| Display_Name | Warfarin
|
| Preferred_Name | Warfarin
|
| FDA_UNII_Code | 5Q7ZVV76EI
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C19H16O4
|
| CAS_Registry | 81-81-2
|
| NSC Number | 59813
|
| NCI_Drug_Dictionary_ID | 39740
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| Legacy Concept Name | Warfarin
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| type | |
| ALT_DEFINITION | A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).
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| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39740
|
| Accepted_Therapeutic_Use_For | Pulmonary embolism and thromboembolic disorders, treatment and prophylaxis; Venous thrombosis, prophylaxis and treatment
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0043031
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