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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C934
http://purl.obolibrary.org/obo/NCIT_C934
|
|---|---|
| Preferred Name | Vindesine |
| Definitions |
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04) |
|---|---|
| prefLabel | Vindesine
|
| label | Vindesine
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:36373
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| PDQ_Closed_Trial_Search_ID | 39732
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| code | C934
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| prefixIRI | NCIT:C934
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| in_subset | |
| Preferred_Name | Vindesine
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| FDA_UNII_Code | RSA8KO39WH
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| Contributing_Source | FDA
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| Chemical_Formula | C43H55N5O7
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| Maps_To | Vindesine
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| CAS_Registry | 53643-48-4
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| NCI_Drug_Dictionary_ID | 39732
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| Legacy Concept Name | Vindesine
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of plant drugs called vinca alkaloids.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39732
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0042682
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| Delete | Subject | Author | Type | Created |
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