Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C933 http://purl.obolibrary.org/obo/NCIT_C933
Preferred Name	Vincristine
Definitions	A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
label	Vincristine
prefLabel	Vincristine
Legacy Concept Name	Vincristine
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C177406 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 http://purl.obolibrary.org/obo/NCIT_C177383 See more See less
Preferred_Name	Vincristine
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
Is_PCDC_GCT_Permissible_Value_For_Variable	http://purl.obolibrary.org/obo/NCIT_C274
Chemical_Formula	C46H56N4O10
Display_Name	Vincristine
Maps_To	Vincristine
Has_Target	http://purl.obolibrary.org/obo/NCIT_C129655
UMLS_CUI	C0042679
FDA_UNII_Code	5J49Q6B70F
prefixIRI	NCIT:C933
Accepted_Therapeutic_Use_For	Lymphoma, Hodgkins, Non-Hodgkins; Malignant thymoma; Multiple myeloma; Osteogenic sarcoma; Ovarian cancer; Pheochromocytoma; Retinoblastoma; Rhabdomyosarcoma; Soft tissue sarcoma; Testicular cancer; Wilms tumor Acute leukemia; Brain tumors; Chronic lymphocytic leukemia; Gestational trophoblastic neoplasms; Head and Neck squamous cell carcinoma; Kaposis sarcoma; Liver cancer;
Contributing_Source	CTRP FDA PCDC
subClassOf	http://purl.obolibrary.org/obo/NCIT_C932 http://purl.obolibrary.org/obo/NCIT_C67422
CHEBI_ID	CHEBI:28445
Has_Salt_Form	http://purl.obolibrary.org/obo/NCIT_C1739
code	C933
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	The active ingredient in a drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Vincristine is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent.
Semantic_Type	Organic Chemical Pharmacologic Substance
CAS_Registry	57-22-7

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