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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C930
http://purl.obolibrary.org/obo/NCIT_C930
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|---|---|
| Preferred Name | Vinblastine |
| Definitions |
A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04) |
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| prefLabel | Vinblastine
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| label | Vinblastine
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:27375
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| PDQ_Closed_Trial_Search_ID | 42951
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| code | C930
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| Has_Target | |
| prefixIRI | NCIT:C930
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| in_subset |
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| Display_Name | Vinblastine
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| Preferred_Name | Vinblastine
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| FDA_UNII_Code | 5V9KLZ54CY
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| Contributing_Source |
CTRP
FDA
PCDC
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| Chemical_Formula | C46H58N4O9
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| Maps_To | Vinblastine
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| CAS_Registry | 865-21-4
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| NSC Number | 90636
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| NCI_Drug_Dictionary_ID | 42951
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| Legacy Concept Name | Vinblastine
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| Is_PCDC_GCT_Permissible_Value_For_Variable | |
| type | |
| ALT_DEFINITION | The active ingredient in a drug used together with other drugs to treat several types of cancer, including advanced Hodgkin lymphoma and advanced testicular germinal-cell cancers. It is also being studied in the treatment of other types of cancer. Vinblastine comes from the periwinkle plant Vinca rosea Linn. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of vinca alkaloid and a type of antimitotic agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42951
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| Accepted_Therapeutic_Use_For | Bladder cancer; Breast cancer; Choriocarcinoma; Germ cell tumors; Idiopathic thrombocytopenic purpura; Kaposi sarcoma; Letterer-Siwe disease; Various Lymphomas; Melanoma; Mycosis fungoides; Prostate cancer; Testicular cancer
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0042670
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