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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C928
http://purl.obolibrary.org/obo/NCIT_C928
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|---|---|
| Preferred Name | Verapamil |
| Definitions |
A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
|---|---|
| prefLabel | Verapamil
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| label | Verapamil
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:9948
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| PDQ_Closed_Trial_Search_ID | 39730
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| code | C928
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| prefixIRI | NCIT:C928
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| in_subset |
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| Display_Name | Verapamil
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| Preferred_Name | Verapamil
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| FDA_UNII_Code | CJ0O37KU29
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C27H38N2O4
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| Maps_To | Verapamil
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| CAS_Registry | 52-53-9
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| NCI_Drug_Dictionary_ID | 39730
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| Legacy Concept Name | Verapamil
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39730
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0042523
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