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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C92590
http://purl.obolibrary.org/obo/NCIT_C92590
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|---|---|
| Preferred Name | Anti-AGS-5 Antibody-Drug Conjugate ASG-5ME |
| Definitions |
An antibody drug conjugate (ADC) containing the fully human IgG2k monoclonal antibody targeting an epitope of SLC44A4 (AGS-5) linked, via a valine-citrulline (vc) maleimidocaproyl (mc) linker, to the antimicrotubulin drug monomethyl auristatin E (MMAE), with potential antineoplastic activity. The monoclonal antibody moiety of ASG-5ME selectively binds to AGS-5. After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and tumor cell apoptosis. SLC44A4, potentially a sodium-dependent transmembrane transport protein, is overexpressed on more than 80 percent of samples derived from patients with pancreatic, prostate and gastric cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antibody drug conjugate (ADC) containing the fully human IgG2k monoclonal antibody targeting an epitope of SLC44A4 (AGS-5) linked, via a valine-citrulline (vc) maleimidocaproyl (mc) linker, to the antimicrotubulin drug monomethyl auristatin E (MMAE), with potential antineoplastic activity. The monoclonal antibody moiety of ASG-5ME selectively binds to AGS-5. After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and tumor cell apoptosis. SLC44A4, potentially a sodium-dependent transmembrane transport protein, is overexpressed on more than 80 percent of samples derived from patients with pancreatic, prostate and gastric cancers. |
|---|---|
| prefLabel | Anti-AGS-5 Antibody-Drug Conjugate ASG-5ME
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| label | Anti-AGS-5 Antibody-Drug Conjugate ASG-5ME
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| PDQ_Closed_Trial_Search_ID | 682506
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| code | C92590
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| Has_Target | |
| prefixIRI | NCIT:C92590
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| in_subset |
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| Display_Name | Anti-AGS-5 Antibody-Drug Conjugate ASG-5ME
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| Preferred_Name | Anti-AGS-5 Antibody-Drug Conjugate ASG-5ME
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| Contributing_Source | CTRP
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| Maps_To | Anti-AGS-5 Antibody-Drug Conjugate ASG-5ME
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| NCI_Drug_Dictionary_ID | 682506
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 682506
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3696055
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