loading...| Preferred Name | Apalutamide | |
| Synonyms |
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|
| Definitions |
A small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. Apalutamide binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C92574 |
|
| Accepted_Therapeutic_Use_For |
non-metastatic castration-resistant prostate cancer |
|
| CAS_Registry |
956104-40-8 |
|
| code |
C92574 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. Apalutamide binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells. |
|
| Display_Name |
Apalutamide |
|
| FDA_UNII_Code |
4T36H88UA7 |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Apalutamide |
|
| Maps_To |
Apalutamide |
|
| NCI_Drug_Dictionary_ID |
683082 |
|
| PDQ_Closed_Trial_Search_ID |
683082 |
|
| PDQ_Open_Trial_Search_ID |
683082 |
|
| Preferred_Name |
Apalutamide |
|
| prefixIRI |
NCIT:C92574 |
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| prefLabel |
Apalutamide |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C2985183 |
|
| subClassOf |