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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C91860
http://purl.obolibrary.org/obo/NCIT_C91860
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|---|---|
| Preferred Name | Disintegrin and Metalloproteinase Domain-Containing Protein 10 |
| Definitions |
Disintegrin and metalloproteinase domain-containing protein 10 (748 aa, ~84 kDa) is encoded by the human ADAM10 gene. This protein plays a role in the mediation of proteolysis of plasma membrane proteins.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Disintegrin and metalloproteinase domain-containing protein 10 (748 aa, ~84 kDa) is encoded by the human ADAM10 gene. This protein plays a role in the mediation of proteolysis of plasma membrane proteins. |
|---|---|
| prefLabel | Disintegrin and Metalloproteinase Domain-Containing Protein 10
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| label | Disintegrin and Metalloproteinase Domain-Containing Protein 10
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| code | C91860
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| prefixIRI | NCIT:C91860
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| OMIM_Number | 602192
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| in_subset | |
| Display_Name | Disintegrin and Metalloproteinase Domain-Containing Protein 10
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| Preferred_Name | Disintegrin and Metalloproteinase Domain-Containing Protein 10
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| Contributing_Source | CTRP
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| Swiss_Prot | O14672
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| DesignNote | Disintegrin and metalloproteinase domain-containing protein 10 cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form, mediates alpha-secretase cleavage of amyloid precursor protein and regulates notch signaling through proteolysis. Other ADAM10 substrates include heparin-binding epidermal growth-like factor, ephrin-A2, cellular prion protein and the adhesion molecule L1. (UniProt)
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| type | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C2984597
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