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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Uracil Mustard | |
| Synonyms |
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| Definitions |
An alkylating derivative of the pyrimidine nucleobase uracil that is bound to nitrogen mustard, with antineoplastic activity. Uramustine alkylates and damages DNA by binding to the guanine and cytosine moieties of DNA. This leads to cross-linking of DNA, which inhibits DNA synthesis and promotes cell death in rapidly metabolizing cells, such as cancer cells. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C918 |
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| CAS_Registry |
66-75-1
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| CHEBI_ID |
CHEBI:9884
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| Chemical_Formula |
C8H11Cl2N3O2
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| code |
C918
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| Contributing_Source |
FDA
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|
| definition |
An alkylating derivative of the pyrimidine nucleobase uracil that is bound to nitrogen mustard, with antineoplastic activity. Uramustine alkylates and damages DNA by binding to the guanine and cytosine moieties of DNA. This leads to cross-linking of DNA, which inhibits DNA synthesis and promotes cell death in rapidly metabolizing cells, such as cancer cells.
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| FDA_UNII_Code |
W7KQ46GJ8U
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| in_subset | ||
| label |
Uracil Mustard
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|
| Legacy Concept Name |
Uracil_Mustard
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| NSC Number |
34462
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| Preferred_Name |
Uracil Mustard
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| prefixIRI |
NCIT:C918
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| prefLabel |
Uracil Mustard
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI |
C0041920
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| subClassOf |
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