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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C91736
http://purl.obolibrary.org/obo/NCIT_C91736
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|---|---|
| Preferred Name | Prexigebersen |
| Definitions |
A liposomal formulation containing the antisense oligodeoxynucleotide (ODN) growth factor receptor-bound protein 2 (Grb2), with potential antineoplastic activity. Upon administration, liposome-incorporated Grb2 antisense oligodeoxynucleotide binds directly to and blocks Grb2 mRNA, thereby preventing Grb2 protein synthesis, leading to inhibition of cell proliferation of cancer cells overexpressing Grb2. Grb2, an adaptor protein involved in growth signaling pathways, is upregulated in certain tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A liposomal formulation containing the antisense oligodeoxynucleotide (ODN) growth factor receptor-bound protein 2 (Grb2), with potential antineoplastic activity. Upon administration, liposome-incorporated Grb2 antisense oligodeoxynucleotide binds directly to and blocks Grb2 mRNA, thereby preventing Grb2 protein synthesis, leading to inhibition of cell proliferation of cancer cells overexpressing Grb2. Grb2, an adaptor protein involved in growth signaling pathways, is upregulated in certain tumor cells. |
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| prefLabel | Prexigebersen
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| label | Prexigebersen
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| NCI_META_CUI | CL421657
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| PDQ_Closed_Trial_Search_ID | 681815
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| code | C91736
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| Has_Target | |
| prefixIRI | NCIT:C91736
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| in_subset |
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| Display_Name | Liposome-Incorporated Grb2 Antisense Oligodeoxynucleotide
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| Preferred_Name | Prexigebersen
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| FDA_UNII_Code | 8W1O4Y961B
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Prexigebersen
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| CAS_Registry | 202484-91-1
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| NCI_Drug_Dictionary_ID | 681815
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 681815
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| Delete | Subject | Author | Type | Created |
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