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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C91727
http://purl.obolibrary.org/obo/NCIT_C91727
|
|---|---|
| Preferred Name | Tabalumab |
| Definitions |
A human IgG4 monoclonal antibody against B-cell activating factor (BAFF), with potential immunomodulating and antineoplastic activities. Tabalumab binds to and inhibits the activity of both soluble and cell surface-bound BAFF. This may reduce the activity, proliferation and survival of B-cells. A dysregulated expression of BAFF, a member of the tumor necrosis factor (TNF) family of proteins, is often seen in certain autoimmune diseases and certain cancers, and may promote B lymphocyte activation, proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A human IgG4 monoclonal antibody against B-cell activating factor (BAFF), with potential immunomodulating and antineoplastic activities. Tabalumab binds to and inhibits the activity of both soluble and cell surface-bound BAFF. This may reduce the activity, proliferation and survival of B-cells. A dysregulated expression of BAFF, a member of the tumor necrosis factor (TNF) family of proteins, is often seen in certain autoimmune diseases and certain cancers, and may promote B lymphocyte activation, proliferation and survival. |
|---|---|
| prefLabel | Tabalumab
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| label | Tabalumab
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| PDQ_Closed_Trial_Search_ID | 600180
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| code | C91727
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| Has_Target | |
| prefixIRI | NCIT:C91727
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| in_subset |
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| Display_Name | Tabalumab
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| Preferred_Name | Tabalumab
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| FDA_UNII_Code | PQP8VH3MJW
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Tabalumab
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| CAS_Registry | 1143503-67-6
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| NCI_Drug_Dictionary_ID | 600180
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 600180
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C2984518
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