Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C91721
http://purl.obolibrary.org/obo/NCIT_C91721
|
|---|---|
| Preferred Name | Anti-Nucleolin Aptamer AS1411 |
| Definitions |
A 26-base guanine-rich oligodeoxynucleotide aptamer with potential apoptotic induction activity. Upon administration, anti-nucleolin aptamer AS1411 targets and binds to nucleolin, a nucleolar phosphoprotein which is overexpressed on the surface of certain cancer cells. Via binding to cell surface nucleolin, AS1411 is internalized and may prevent nucleolin from binding to and stabilizing mRNA of the anti-apoptotic BCL2, thereby destabilizing BCL2 mRNA, leading to a reduction in BCL2 protein synthesis. This may lead to the induction of apoptosis.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A 26-base guanine-rich oligodeoxynucleotide aptamer with potential apoptotic induction activity. Upon administration, anti-nucleolin aptamer AS1411 targets and binds to nucleolin, a nucleolar phosphoprotein which is overexpressed on the surface of certain cancer cells. Via binding to cell surface nucleolin, AS1411 is internalized and may prevent nucleolin from binding to and stabilizing mRNA of the anti-apoptotic BCL2, thereby destabilizing BCL2 mRNA, leading to a reduction in BCL2 protein synthesis. This may lead to the induction of apoptosis. |
|---|---|
| prefLabel | Anti-Nucleolin Aptamer AS1411
|
| label | Anti-Nucleolin Aptamer AS1411
|
| PDQ_Closed_Trial_Search_ID | 565948
|
| code | C91721
|
| Has_Target | |
| prefixIRI | NCIT:C91721
|
| in_subset |
See more
See less
|
| Display_Name | Anti-Nucleolin Aptamer AS1411
|
| Preferred_Name | Anti-Nucleolin Aptamer AS1411
|
| Contributing_Source | CTRP
|
| Maps_To | Anti-Nucleolin Aptamer AS1411
|
| NCI_Drug_Dictionary_ID | 565948
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 565948
|
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
|
| UMLS_CUI | C1744513
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |