Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C91711 http://purl.obolibrary.org/obo/NCIT_C91711
Preferred Name	Trebananib
Definitions	An angiopoietin (Ang) 1 and 2 neutralizing peptibody, with potential antiangiogenic activity. AMG 386 targets and binds to Ang1 and Ang2, thereby preventing the interaction of the angiopoietins with their target tie2 receptors. This may inhibit angiogenesis and may eventually lead to an inhibition of tumor cell proliferation.
Type	http://www.w3.org/2002/07/owl#Class

definition	An angiopoietin (Ang) 1 and 2 neutralizing peptibody, with potential antiangiogenic activity. AMG 386 targets and binds to Ang1 and Ang2, thereby preventing the interaction of the angiopoietins with their target tie2 receptors. This may inhibit angiogenesis and may eventually lead to an inhibition of tumor cell proliferation.
prefLabel	Trebananib
label	Trebananib
PDQ_Closed_Trial_Search_ID	423474
code	C91711
Has_Target	http://purl.obolibrary.org/obo/NCIT_C18056 http://purl.obolibrary.org/obo/NCIT_C18042
prefixIRI	NCIT:C91711
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Display_Name	Trebananib
Preferred_Name	Trebananib
FDA_UNII_Code	X8Y5U6NC7E
Contributing_Source	CTRP FDA
Maps_To	Trebananib
CAS_Registry	894356-79-7
NCI_Drug_Dictionary_ID	423474
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C1742
PDQ_Open_Trial_Search_ID	423474
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
UMLS_CUI	C1541521

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