Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Id http://purl.obolibrary.org/obo/NCIT_C916
http://purl.obolibrary.org/obo/NCIT_C916
Preferred Name

Coenzyme Q10
Definitions
A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme Q10 functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme Q10 may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme Q10 functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme Q10 may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. (NCI04)
label
Coenzyme Q10
prefLabel
Coenzyme Q10
Legacy Concept Name
Coenzyme-Q
in_subset
Preferred_Name
Coenzyme Q10
Is_Value_For_GDC_Property
Chemical_Formula
C59H90O4
Display_Name
Coenzyme Q10
Maps_To
Coenzyme Q10
PDQ_Open_Trial_Search_ID
39187
UMLS_CUI
C0056077
FDA_UNII_Code
EJ27X76M46
prefixIRI
NCIT:C916
Accepted_Therapeutic_Use_For
Chronic heart failure; mitochondrial cytopathies
NCI_Drug_Dictionary_ID
39187
Contributing_Source
CTRP
FDA
subClassOf
CHEBI_ID
CHEBI:46245
code
C916
type
ALT_DEFINITION
A nutrient that the body needs in small amounts to function and stay healthy. Coenzyme Q10 helps mitochondria (small structures in the cell) make energy. It is an antioxidant that helps prevent cell damage caused by free radicals (highly reactive chemicals). Coenzyme Q10 is fat-soluble (can dissolve in fats and oils) and is found in fatty fish, beef, soybeans, peanuts, and spinach. It is being studied in the prevention and treatment of some types of cancer and heart disease and in the relief of side effects caused by some cancer treatments.
NSC Number
140865
PDQ_Closed_Trial_Search_ID
39187
Semantic_Type
Organic Chemical
Pharmacologic Substance
CAS_Registry
303-98-0
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